N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide

Base Information

Chemical Name:N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide
CAS No.:165404-69-3
Molecular Formula:C₁₉H₂₇NO₃S₂Si
Molecular Weight:409.646
Hs Code.:

Synonyms:N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide

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Chemical Property of N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide

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Technology Process of N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide

There total 5 articles about N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 38210-25-2
4H-1,3-benzodioxine-2,4-dione

: 165404-65-9
(6-Azidomethyl-[1,2]dithiin-3-ylmethoxy)-tert-butyl-dimethyl-silane

: 165404-69-3
N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide

: 2-Hydroxy-benzoic acid 2-{[6-(tert-butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-carbamoyl}-phenyl ester

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; for 2.5h;
DOI:10.1021/jm00014a016

Reference yield:

: 165404-83-1
3-[(tert-butyldimethylsilyloxy)methyl]-6-(hydroxymethyl)-1,2-dithiin

: 165404-69-3
N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74.5 percent / diphenyl phosphorazidate, DBU / toluene / 16 h / 0 - 20 °C

2: 22 percent / Ph₃P, H₂O / tetrahydrofuran / 2.5 h

With diphenyl phosphoryl azide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; toluene;
DOI:10.1021/jm00014a016

Reference yield:

: 2,5-bis<(2-cyanoethyl)thio>-2,4-hexadiene-1,6-diol

: 165404-69-3
N-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethyl]-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 49.3 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

2: 1.) t-BuOK, 2.) aq. K₃FeCN₆ / 1.) eter, 11 min, 2.) eter, 12 min

3: 74.5 percent / diphenyl phosphorazidate, DBU / toluene / 16 h / 0 - 20 °C

4: 22 percent / Ph₃P, H₂O / tetrahydrofuran / 2.5 h

With 1H-imidazole; diphenyl phosphoryl azide; potassium tert-butylate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; potassium hexacyanoferrate(III); In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00014a016