N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Base Information

Chemical Name:N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide
CAS No.:441797-09-7
Molecular Formula:C₂₁H₂₄N₄O₆S₂
Molecular Weight:492.577
Hs Code.:

Synonyms:N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

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Chemical Property of N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

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Technology Process of N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

There total 9 articles about N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38768-62-6
methyl (2-methoxyphenoxy) ethanoate

: 441797-09-7
N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C

1.2: 24 h / 20 - 32 °C

2.1: sodium methylate / methanol / 0.5 h

2.2: 24 h / 10 °C

3.1: potassium carbonate / dimethyl sulfoxide / 0.5 h

3.2: 4.17 h

4.1: trichlorophosphate / N,N-dimethyl-aniline / 3.5 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C

6.1: potassium tert-butylate / 149 h / 60 °C

With potassium tert-butylate; sodium methylate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-aniline; mineral oil;
DOI:10.1021/jm3009103

Reference yield:

: 329924-14-3
5-(o-methoxyphenoxy)-2-thioxo-dihydro-pyrimidine-4,6-dione

: 441797-09-7
N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h

1.2: 4.17 h

2.1: trichlorophosphate / N,N-dimethyl-aniline / 3.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C

4.1: potassium tert-butylate / 149 h / 60 °C

With potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dimethyl sulfoxide; N,N-dimethyl-aniline;
DOI:10.1021/jm3009103

Reference yield:

: 1878-85-9
(2-methoxyphenoxy)acetic acid

: 441797-09-7
N-(6-(2-hydroxyethoxy)-2-methylsulfanyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 3 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C

2.2: 24 h / 20 - 32 °C

3.1: sodium methylate / methanol / 0.5 h

3.2: 24 h / 10 °C

4.1: potassium carbonate / dimethyl sulfoxide / 0.5 h

4.2: 4.17 h

5.1: trichlorophosphate / N,N-dimethyl-aniline / 3.5 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C

7.1: potassium tert-butylate / 149 h / 60 °C

With thionyl chloride; potassium tert-butylate; sodium methylate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-aniline; mineral oil;
DOI:10.1021/jm3009103