6-(3-Chlorophenyl)-N,N-bis(2-pyridinylmethyl)-2-pyridinemethanamine

Base Information

Chemical Name:6-(3-Chlorophenyl)-N,N-bis(2-pyridinylmethyl)-2-pyridinemethanamine
CAS No.:502925-37-3
Molecular Formula:C₂₄H₂₁ClN₄
Molecular Weight:400.911
Hs Code.:
DSSTox Substance ID:DTXSID001163356

Synonyms:DTXSID001163356;6-(3-Chlorophenyl)-N,N-bis(2-pyridinylmethyl)-2-pyridinemethanamine;502925-37-3

Suppliers and Price of 6-(3-Chlorophenyl)-N,N-bis(2-pyridinylmethyl)-2-pyridinemethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3-Chlorophenyl)-N,N-bis(2-pyridinylmethyl)-2-pyridinemethanamine

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:400.1454744
Heavy Atom Count:29
Complexity:456

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=NC(=C1)CN(CC2=NC(=CC=C2)C3=CC(=CC=C3)Cl)CC4=CC=CC=N4

Technology Process of 6-(3-Chlorophenyl)-N,N-bis(2-pyridinylmethyl)-2-pyridinemethanamine

There total 3 articles about 6-(3-Chlorophenyl)-N,N-bis(2-pyridinylmethyl)-2-pyridinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61704-38-9
6-(3-chloro-phenyl)-pyridine-2-carbaldehyde

: 1539-42-0
bis[(2-pyridyl)methyl]amine

: 502925-37-3
[6-(3-chloro-phenyl)-pyridin-2-ylmethyl]-bis-pyridin-2-ylmethyl-amine

Guidance literature:: 6-(3-chloro-phenyl)-pyridine-2-carbaldehyde; bis[(2-pyridyl)methyl]amine; With thionyl chloride; In methanol; at 20 ℃;

With sodium cyanoborohydride; In methanol; at 20 ℃; Further stages.;
DOI:10.1021/ja028478l

Reference yield:

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 502925-37-3
[6-(3-chloro-phenyl)-pyridin-2-ylmethyl]-bis-pyridin-2-ylmethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / Heating

2.1: SOCl₂ / methanol / 20 °C

2.2: NaBH₃CN / methanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; In methanol; toluene; 1.1: Suzuki coupling;
DOI:10.1021/ja028478l

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 502925-37-3
[6-(3-chloro-phenyl)-pyridin-2-ylmethyl]-bis-pyridin-2-ylmethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / Heating

2.1: SOCl₂ / methanol / 20 °C

2.2: NaBH₃CN / methanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; In methanol; toluene; 1.1: Suzuki coupling;
DOI:10.1021/ja028478l