Technology Process of HU 909
There total 7 articles about HU 909 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
HU 911;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran; diethyl ether;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
With
water; magnesium sulfate;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate; potassium permanganate / water / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / -78 - 0 °C / Inert atmosphere
3.2: 18 h / 0 - 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 15 h / Inert atmosphere; Reflux
5.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere
With
potassium permanganate; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 15 h / Inert atmosphere; Reflux
3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether; hexane;
2.1: Suzuki Coupling;
