N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide

Base Information

• Chemical Name: N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide
• CAS No.: 154255-37-5
• Molecular Formula: C₁₈H₁₄ClN₃O
• Molecular Weight: 323.782
• Mol file: 154255-37-5.mol

Synonyms:N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide

Chemical Property of N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide

There total 3 articles about N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-3-quinoline carboxaldehyde (73568-25-9) + 2-phenylacetylhydrazine (937-39-3) → N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide (154255-37-5)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1002/ardp.19933260812

Reference yield:

Acetanilid (103-84-4) → N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide (154255-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 0 - 75 °C

2: ethanol / Reflux

With trichlorophosphate; In ethanol; 1: Vilsmeier-Haack reaction;

Reference yield:

phenylacetic acid (103-82-2) → N'-[(2-chloroquinolin-3-yl)methylidene]-2-phenylacetohydrazide (154255-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; sulfuric acid / ethanol / 6 h / Reflux

2: ethanol / 5 h / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-014-1308-2

upstream raw materials:

2-chloro-3-quinoline carboxaldehyde

2-phenylacetylhydrazine

Acetanilid

phenylacetic acid