(S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

Base Information

Chemical Name:(S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one
CAS No.:850211-61-9
Molecular Formula:C₃₆H₃₇NO₅
Molecular Weight:563.693
Hs Code.:

Synonyms:(S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

Suppliers and Price of (S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

There total 1 articles about (S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 131685-53-5,101711-78-8
(S)-4-benzyl-3-propionyl-2-oxazolidinone

: 111865-84-0
(2S)-2-methyl-3-(trityloxy)propionaldehyde

: 850211-61-9
(S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

Guidance literature:: (S)-4-benzyl-3-propionyl-2-oxazolidinone; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In hexane; dichloromethane; at 0 ℃;

(2S)-2-methyl-3-(trityloxy)propionaldehyde; In tetrahydrofuran; hexane; at -78 - 0 ℃;

With dihydrogen peroxide; In various solvents; at 20 ℃; for 1h;
DOI:10.1021/ol050455z

Reference yield: 91.0%

: 850211-61-9
(S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

: 69739-34-0
t-butyldimethylsiyl triflate

: 850211-62-0
(S)-4-Benzyl-3-[(2S,3R,4S)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-trityloxy-pentanoyl]-oxazolidin-2-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/ol050455z

Reference yield:

: 850211-61-9
(S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one

: tert-Butyl-[(Z)-(1R,2R,3S,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-1-((S)-1-methyl-2-trityloxy-ethyl)-octa-5,7-dienyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 0 °C

2.1: 80 percent / LiBH₄; EtOH / tetrahydrofuran / 13 h / 0 - 20 °C

3.1: pyridine*SO₂; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 3 h / 20 °C

4.1: tetrahydrofuran / 7 h / -78 °C

4.2: 1.25 g / NaOH; H₂O₂ / tetrahydrofuran; H₂O / 4 h / 60 °C

5.1: 82 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / 2 h / -10 °C

6.1: O₃; pyridine; Sudan III / CH₂Cl₂; methanol / 0.05 h / -78 °C

6.2: 83 percent / dimethylsulfide / CH₂Cl₂; methanol / 4 h / 20 °C

With pyridine; 2,6-dimethylpyridine; lithium borohydride; ethanol; trifluorormethanesulfonic acid; oil scarlet; sulfur(IV) oxide * pyridine; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 4.1: Brown crootylation;
DOI:10.1021/ol050455z