Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester

Base Information

• Chemical Name: Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester
• CAS No.: 213622-12-9
• Molecular Formula: C₈₂H₁₃₂O₁₄
• Molecular Weight: 1341.94
• Mol file: 213622-12-9.mol

Synonyms:Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester

Chemical Property of Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester

There total 3 articles about Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Malonic acid mono-(3,5-bis-dodecyloxy-benzyl) ester (199192-22-8) + 1-(5,5-dimethyl-{1,3}-dioxane-2-yl)-3,5-di(hydroxymethyl)-benzene (213622-11-8) → Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester (213622-12-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1934::AID-ANIE1934>3.0.CO;2-M

Reference yield:

2-(3,5-Dibromo-phenyl)-5,5-dimethyl-[1,3]dioxane (213622-10-7) → Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester (213622-12-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) tert-BuLi / 1.) THF, -78 to 0 deg C, 2.) DMF, -78 to 0 deg C

2: DIBAL-H / CH₂Cl₂ / 0 °C

3: 72 percent / DCC, DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; tert.-butyl lithium; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1934::AID-ANIE1934>3.0.CO;2-M

Reference yield:

5-(5,5-Dimethyl-[1,3]dioxan-2-yl)-benzene-1,3-dicarbaldehyde (950608-82-9) → Malonic acid 3,5-bis-dodecyloxy-benzyl ester 3-[2-(3,5-bis-dodecyloxy-benzyloxycarbonyl)-acetoxymethyl]-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-benzyl ester (213622-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: DIBAL-H / CH₂Cl₂ / 0 °C

2: 72 percent / DCC, DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1934::AID-ANIE1934>3.0.CO;2-M

upstream raw materials:

Malonic acid mono-(3,5-bis-dodecyloxy-benzyl) ester

1-(5,5-dimethyl-{1,3}-dioxane-2-yl)-3,5-di(hydroxymethyl)-benzene

2-(3,5-Dibromo-phenyl)-5,5-dimethyl-[1,3]dioxane

5-(5,5-Dimethyl-[1,3]dioxan-2-yl)-benzene-1,3-dicarbaldehyde