N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester

Base Information

• Chemical Name: N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester
• CAS No.: 882035-35-0
• Molecular Formula: C₂₇H₃₃N₃O₄
• Molecular Weight: 463.577
• Mol file: 882035-35-0.mol

Synonyms:N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester

Chemical Property of N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester

There total 5 articles about N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester (882035-32-7) → N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester (882035-35-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; under 760 Torr;

DOI:10.1016/j.tetasy.2005.12.006

Reference yield:

[(S)-1-(4-Nitro-phenyl)-ethyl]-[1-phenyl-meth-(E)-ylidene]-amine → N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester (882035-35-0)

Guidance literature:

Multi-step reaction with 4 steps

1: TEA / CH₂Cl₂ / Heating

2: 48 h / Heating

3: TEA / CH₂Cl₂ / 0 - 20 °C

4: H₂ / Pd/C / methanol / 20 °C / 760 Torr

With TEA; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.tetasy.2005.12.006

Reference yield:

(R)-3-Bromo-4-methyl-1-[(S)-1-(4-nitro-phenyl)-ethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one (882035-23-6) → N-{1-[1-(4-amino-phenyl)-ethyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid methyl ester (882035-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 h / Heating

2: TEA / CH₂Cl₂ / 0 - 20 °C

3: H₂ / Pd/C / methanol / 20 °C / 760 Torr

With TEA; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.tetasy.2005.12.006

upstream raw materials:

N-allyl-N-{4-methyl-1-[1-(4-nitro-phenyl)-ethyl]-2-oxo-6-phenyl-1,2,5,6-tetrahydro-pyridin-3-yl}-malonamic acid methyl ester

(R)-3-Bromo-4-methyl-1-[(S)-1-(4-nitro-phenyl)-ethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one

(R)-3-Allylamino-4-methyl-1-[(S)-1-(4-nitro-phenyl)-ethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one

2-bromo-3-methyl-but-2-enoyl chloride

Downstream raw materials:

C₃₈H₅₁N₅O₈