benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester

Base Information

• Chemical Name: benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester
• CAS No.: 1392506-52-3
• Molecular Formula: C₄₃H₄₄N₄O₅
• Molecular Weight: 696.846

Synonyms:benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester

Chemical Property of benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester

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Technology Process of benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester

There total 1 articles about benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

tert-butyl (2-(diphenylmethylene)-1-(prop-2-yn-1-yl)hydrazine-1-carbonyl)-D-phenylalaninate (1392506-36-3) + tert-butyl 3-iodo-1H-indol-1-carboxylate (192189-07-4) → benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester (1392506-52-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; In N,N-dimethyl-formamide; for 12h; Inert atmosphere;

DOI:10.1021/ol302021n

Reference yield: 40.0%

benzhydrylidene aza-N-Boc-3-indolylpropargylglycinyl-D-phenylalanine tert-butyl ester (1392506-52-3) → (2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(N'-Boc-3'-indoylmethylene)imidazolidin-2-one (1392506-58-9)

Guidance literature:

With sodium hydride; In acetonitrile; mineral oil; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol302021n

upstream raw materials:

tert-butyl (2-(diphenylmethylene)-1-(prop-2-yn-1-yl)hydrazine-1-carbonyl)-D-phenylalaninate

tert-butyl 3-iodo-1H-indol-1-carboxylate

Downstream raw materials:

(2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(N'-Boc-3'-indoylmethylene)imidazolidin-2-one

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