2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione

Base Information

Chemical Name:2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione
CAS No.:1257243-89-2
Molecular Formula:C₂₆H₂₆N₂O₄
Molecular Weight:430.503
Hs Code.:

Synonyms:2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione

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Chemical Property of 2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione

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Technology Process of 2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione

There total 5 articles about 2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1257243-87-0
2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylprop-2-ynyl}isoindole-1,3-dione

: 1257243-89-2
2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione

Guidance literature:: With 10% palladium on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 3h; under 2250.23 Torr;
DOI:10.1021/jm101179e

Reference yield:

: 1204484-03-6
5-(4-bromophenoxy)-2-isopropoxypyridine

: 1257243-89-2
2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 70 °C

2: 10% palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 3 h / 20 °C / 2250.23 Torr

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10% palladium on activated carbon; hydrogen; triethylamine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1021/jm101179e

Reference yield:

: 1257243-84-7
5-(4-bromophenoxy)-2-chloropyridine

: 1257243-89-2
2-{(S)-3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 1 h / 20 °C / Cooling

1.2: 3 h / 85 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 70 °C

3.1: 10% palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 3 h / 20 °C / 2250.23 Torr

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10% palladium on activated carbon; hydrogen; sodium hydride; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 2.1: Sonogashira coupling;
DOI:10.1021/jm101179e