3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid

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Chemical Name:3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid
CAS No.:1403384-22-4
Molecular Formula:C₃₁H₄₉N₃O₆S₂
Molecular Weight:623.879
Hs Code.:

Synonyms:3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid

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Chemical Property of 3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid

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Technology Process of 3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid

There total 12 articles about 3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1403384-20-2
methyl 3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoate

: 1403384-22-4
3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid

Guidance literature:: methyl 3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoate; With methanol; sodium hydroxide; at 20 ℃;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 3284-51-3
ethyl 5-methyl-1H-pyrrole-2-carboxylate

: 1403384-22-4
3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

1.2: 50 °C

2.1: chlorosulfonic acid / 36 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride; water / ethanol / Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

6.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 100 °C

7.1: sodium hydroxide; methanol / 20 °C

7.2: pH 2

With hydrogenchloride; methanol; chlorosulfonic acid; N-Bromosuccinimide; water; sodium hydride; potassium carbonate; caesium carbonate; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil; 6.1: Suzuki Coupling;

Reference yield:

: 6310-21-0
2-(1,1-dimethylethyl)-benzenamine

: 1403384-22-4
3-(5-(3-(tert-butyl)-4-(N-(tert-butyl)sulfamoyl)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0.75 h / -10 °C

2.2: 5 - 20 °C

3.1: triethylamine / toluene / 4 h / Reflux

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 100 °C

6.1: sodium hydroxide; methanol / 20 °C

6.2: pH 2

With hydrogenchloride; methanol; N-Bromosuccinimide; potassium acetate; caesium carbonate; triethylamine; sodium hydroxide; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 5.1: Suzuki Coupling;