(R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

Base Information

Chemical Name:(R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one
CAS No.:1188918-65-1
Molecular Formula:C₁₆H₁₅FN₄O₆
Molecular Weight:378.317
Hs Code.:

Synonyms:(R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

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Chemical Property of (R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

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Technology Process of (R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

There total 8 articles about (R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188337-61-2
(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-oxazolidin-2-one

: 1188918-65-1
(R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

Guidance literature:: (R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-oxazolidin-2-one; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 627541-90-6
(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-oxazolidin-2-one

: 1188918-65-1
(R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

2.1: triethylamine / 1,4-dioxane / 1 h / 20 °C

2.2: 19 h / 80 °C

3.1: sodium tetrahydroborate; water / tetrahydrofuran; methanol / 0.67 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 7 h / 50 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; potassium carbonate; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1188330-70-2
(R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one

: 1188918-65-1
(R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

3.1: triethylamine / 1,4-dioxane / 1 h / 20 °C

3.2: 19 h / 80 °C

4.1: sodium tetrahydroborate; water / tetrahydrofuran; methanol / 0.67 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 7 h / 50 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; potassium acetate; potassium carbonate; caesium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;