6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Base Information

Chemical Name:6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one
CAS No.:1349820-83-2
Molecular Formula:C₃₄H₃₂FNO₄
Molecular Weight:537.631
Hs Code.:

Synonyms:6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

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Chemical Property of 6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

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Technology Process of 6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

There total 9 articles about 6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1349820-67-2
6-butyl-3-iodo-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

: 283173-82-0
[3-(4-fluorophenoxy)phenyl]boronic acid

: 1349820-83-2
6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm200718m

Reference yield:

: 1349820-44-5
6-butyl-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

: 1349820-83-2
6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; potassium iodide; sodium hydroxide / methanol / 2 h / 20 °C

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; sodium carbonate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere; Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iodine; sodium carbonate; potassium iodide; sodium hydroxide; In methanol; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm200718m

Reference yield:

: 28583-62-2
N-(4-butyryl-3-hydroxyphenyl)acetamide

: 1349820-83-2
6-butyl-3-(3-(4-fluorophenoxy)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / 0.5 h / 0 °C

2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 3102.97 Torr

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 75 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: potassium hydroxide / ethanol; water / 0 °C / Reflux

5.1: acetic acid / benzene / Reflux

5.2: 0.25 h / Reflux

6.1: iodine; potassium iodide; sodium hydroxide / methanol / 2 h / 20 °C

7.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; sodium carbonate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere; Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium tetrahydroborate; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; iodine; sodium hydride; sodium carbonate; acetic acid; potassium iodide; potassium hydroxide; sodium hydroxide; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; benzene; 5.1: Conrad-Limpach synthesis / 7.1: Suzuki coupling;
DOI:10.1021/jm200718m