(5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate

Base Information

Chemical Name:(5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate
CAS No.:1432660-15-5
Molecular Formula:C₂₈H₃₅ClN₅O₇P
Molecular Weight:620.042
Hs Code.:

Synonyms:(5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate

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Chemical Property of (5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate

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Technology Process of (5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate

There total 9 articles about (5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 26086-60-2
2-azido-4'-chloroacetophenone

: 1432660-14-4
(5-isothiocyanato-1H-indazol-1-yl)methyl 2-( di-tert-butoxyphosphoryloxy)ethylcarbamate

: 1432660-15-5
(5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate

Guidance literature:: With triphenylphosphine; In 1,4-dioxane; at 90 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2013.03.075

Reference yield:

: 1432660-25-7
(5-amino-1H-indazol-1-yl)methyl 2-(di-tert-butoxyphosphoryloxy)ethylcarbamate

: 1432660-15-5
(5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: triphenylphosphine / 1,4-dioxane / 0.5 h / 90 °C

With triphenylphosphine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.075

Reference yield:

: 5401-94-5
5-nitroindazole

: 1432660-15-5
(5-(5-(4-chlorophenyl)oxazol-2-ylamino )-1H-indazol-1-yl)methyl 2-(di-tertbutoxyphosphoryloxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / water; ethanol / 20 - 85 °C

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3: dichloromethane

4: 1H-tetrazole / dichloromethane / 20 °C

5: dihydrogen peroxide / dichloromethane; water / 1 h / 0 - 20 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 24 h / 760.05 Torr / Inert atmosphere

7: dichloromethane / 1 h / 20 °C

8: triphenylphosphine / 1,4-dioxane / 0.5 h / 90 °C

With 1H-tetrazole; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; triethylamine; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2013.03.075