2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

Base Information

Chemical Name:2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester
CAS No.:137219-70-6
Molecular Formula:C₂₄H₃₁NO₂
Molecular Weight:365.516
Hs Code.:

Synonyms:2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

Suppliers and Price of 2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

There total 2 articles about 2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 21003-56-5,21003-57-6,23294-41-9,42287-48-9,56210-72-1,10024-74-5
(1S,1'S)-bis(1-phenylethyl)amine

: 53913-96-5
tert-butyl 2-(bromomethyl)acrylate

: 137219-70-6
2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 - 70 ℃; for 18h;
DOI:10.1016/S0040-4039(00)91786-6

Reference yield:

: 21003-56-5,21003-57-6,23294-41-9,42287-48-9,56210-72-1,10024-74-5
(1S,1'S)-bis(1-phenylethyl)amine

: 2-chloromethyl-acrylic acid tert-butyl ester

: 137219-70-6
2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

Guidance literature:: In toluene; at 35 - 45 ℃; Large scale;
DOI:10.1021/op020091f

Reference yield:

: 137219-70-6
2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester

: 129980-28-5
tert-butyl (S,S)-N-{1-[3-amino-2-(tert-butoxycarbonyl)-propyl]-1-cyclopentylcarbonyl}-O₄-tert-butyltyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LDA / 1) 0 deg C, 1 h, 2) - 50 to - 20 deg C, 6 h

2: 1) 1-hydroxybenztriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 2) H₂ / 2) 20percent Pd(OH)2/C / 1) CH₂Cl₂, 0 deg C to RT, 18 h, 2) EtOH, RT, 60 psi, 18 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium dihydroxide;
DOI:10.1016/S0040-4039(00)91786-6