3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Base Information

Chemical Name:3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide
CAS No.:1113061-15-6
Molecular Formula:C₃₀H₂₇Cl₂F₄NO₇
Molecular Weight:660.446
Hs Code.:

3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Synonyms:3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

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Chemical Property of 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

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Technology Process of 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

There total 7 articles about 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1113061-14-5
1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate

: 1113061-15-6
3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm401549m

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1113061-15-6
3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C

2: potassium carbonate / tetrahydrofuran / 14 h / 0 °C / Reflux

3: potassium tert-butylate / tetrahydrofuran / 1 h / -30 - -20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 72 h / 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With dmap; potassium tert-butylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401549m

Reference yield:

: 151103-09-2
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

: 1113061-15-6
3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / -30 - -20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 72 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With dmap; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm401549m