Clocortolone

Base Information

Chemical Name:Clocortolone
CAS No.:4828-27-7
Molecular Formula:C22H28ClFO4
Molecular Weight:410.913
Hs Code.:
European Community (EC) Number:225-406-7
UNII:N8ZUB7XE0H
DSSTox Substance ID:DTXSID901333489
Nikkaji Number:J106.513K
Wikipedia:Clocortolone
Wikidata:Q5134843
NCI Thesaurus Code:C61684
RXCUI:21249
Metabolomics Workbench ID:43124
Mol file:4828-27-7.mol

Synonyms:clocortolone;clocortolone acetate

Suppliers and Price of Clocortolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Clocortolone
1mg
$ 545.00

Medical Isotopes, Inc.
Clocortolone
0.5 mg
$ 775.00

Medical Isotopes, Inc.
Clocortolone
10 mg
$ 5000.00

Biosynth Carbosynth
Clocortolone
250 mg
$ 300.00

Biosynth Carbosynth
Clocortolone
100 mg
$ 200.00

Biosynth Carbosynth
Clocortolone
50 mg
$ 150.00

Biosynth Carbosynth
Clocortolone
25 mg
$ 100.00

Biosynth Carbosynth
Clocortolone
10 mg
$ 60.00

American Custom Chemicals Corporation
CLOCORTOLONE 95.00%
5MG
$ 3025.00

Total 23 raw suppliers

Chemical Property of Clocortolone

Chemical Property:

Vapor Pressure:3.6E-15mmHg at 25°C
Melting Point:254ºC
Refractive Index:1.579
Boiling Point:566 °C at 760 mmHg
Flash Point:296.1 °C
PSA：74.60000
Density:1.32 g/cm³
LogP:2.99810
Storage Temp.:Refrigerator, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:410.1660152
Heavy Atom Count:28
Complexity:793

Purity/Quality:

99% ^*data from raw suppliers

Clocortolone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1C(=O)CO)C)O)Cl)C)F
Isomeric SMILES:C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)Cl)C)F
Uses Clocortolone can be used in the treatment of skin inflammmation and other skin conditions arising for dermatoses. Corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
Therapeutic Function Glucocorticoid

Technology Process of Clocortolone

There total 4 articles about Clocortolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1355648-15-5
9-chloro-6α-fluoro-11,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione

: 4828-27-7
9α-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:: With trimethylsilyl iodide; isopropyl alcohol; In acetonitrile; at 20 ℃; for 0.25h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 4571-51-1
9β,11-epoxy-6α-fluoro-16α-methyl-17,21-dihydroxy-1,4-diene-3,20-dione 21-acetate

: 4828-27-7
9α-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; water / methanol / 10 h

2: hydrogenchloride / water / 5 h / -15 - -10 °C

3: isopropyl alcohol; trimethylsilyl iodide / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

With hydrogenchloride; trimethylsilyl iodide; water; potassium carbonate; isopropyl alcohol; In methanol; water; acetonitrile;