methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester

Base Information

Chemical Name:methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester
CAS No.:642479-02-5
Molecular Formula:C₂₁H₂₂N₂O₇S
Molecular Weight:446.481
Hs Code.:

methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1<i>H</i>-benzo[<i>e</i>]pyrrolo[1,2-<i>a</i>][1,4]diazepin-2-yl ester

Synonyms:methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester

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Chemical Property of methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester

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Technology Process of methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester

There total 3 articles about methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 642479-01-4
methyl-(2S,4R)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-[(methylsulfonyl)oxy]pyrrolidine-2-carboxylate

: 642479-02-5
methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester

Guidance literature:: With tin(ll) chloride; In methanol; for 2h; Heating;
DOI:10.1016/j.bmcl.2003.08.071

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 642479-02-5
methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / SOCl₂; H₂O / benzene / 2 h / 20 °C

2: 78 percent / TEA / CH₂Cl₂ / 5 h / 0 °C

3: 68 percent / SnCl₂*2H₂O / methanol / 2 h / Heating

With thionyl chloride; TEA; water; tin(ll) chloride; In methanol; dichloromethane; benzene;
DOI:10.1016/j.bmcl.2003.08.071

Reference yield:

: 382137-65-7
methyl-(2S,4R)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]-4-hydroxypyrrolidine-2-carboxylate

: 642479-02-5
methanesulfonic acid 8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / TEA / CH₂Cl₂ / 5 h / 0 °C

2: 68 percent / SnCl₂*2H₂O / methanol / 2 h / Heating

With TEA; tin(ll) chloride; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2003.08.071