3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

Base Information

Chemical Name:3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate
CAS No.:1620239-50-0
Molecular Formula:C₄₀H₄₆N₆O₇
Molecular Weight:722.841
Hs Code.:

3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

Synonyms:3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

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Chemical Property of 3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

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Technology Process of 3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

There total 11 articles about 3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1620011-47-3
3-amino-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

: 1620239-51-1
3-{[(benzyloxy)carbonyl]amino}-7-ethylquinoline-2-carboxylic acid

: 1620239-50-0
3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 76653-07-1
4-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridine

: 1620239-50-0
3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

Guidance literature:: Multi-step reaction with 8 steps

1: potassium nitrate; sulfuric acid / 4 h / 0 - 80 °C

2: acetic acid; hydrogen bromide / water / 0.67 h / 130 °C / Sealed tube

3: trichlorophosphate / 2 h / 110 °C / Sealed tube; Inert atmosphere

4: triethylamine / isopropyl alcohol / 0.5 h / 100 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 67 h / 0 - 20 °C

6: 1 h / 90 °C / Sealed tube

7: iron; acetic acid / water / 0.33 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With sulfuric acid; hydrogen bromide; iron; acetic acid; potassium nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1620011-36-0
4-methoxy-3-nitro-6,7-dihydro-5H-cyclopenta[b]pyridine

: 1620239-50-0
3-{[(3-{[(benzyloxy)carbonyl]amino}-7-ethylquinolin-2-yl)carbonyl]amino}-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; hydrogen bromide / water / 0.67 h / 130 °C / Sealed tube

2: trichlorophosphate / 2 h / 110 °C / Sealed tube; Inert atmosphere

3: triethylamine / isopropyl alcohol / 0.5 h / 100 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 67 h / 0 - 20 °C

5: 1 h / 90 °C / Sealed tube

6: iron; acetic acid / water / 0.33 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogen bromide; iron; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;