C₂₁H₃₀O₇S

Base Information

• Chemical Name: C₂₁H₃₀O₇S
• CAS No.: 226927-03-3
• Molecular Formula: C₂₁H₃₀O₇S
• Molecular Weight: 426.531
• Mol file: 226927-03-3.mol

Synonyms:C₂₁H₃₀O₇S

Chemical Property of C₂₁H₃₀O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₃₀O₇S

There total 6 articles about C₂₁H₃₀O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Toluene-4-sulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxy-5-((S)-2,6,6-trimethyl-5-oxo-tetrahydro-pyran-2-yl)-pentyl ester → C21H30O7S (226927-03-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/S0040-4039(99)00366-4

Reference yield:

Acetic acid (E)-(R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-iodo-but-3-enyl ester (226926-96-1) → C21H30O7S (226927-03-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 40 percent / Cri₉₀₀ NiCl₂ / dimethylsulfoxide / 20 °C

2: 90 percent / NaBH₄, NiCl₂*6H₂O / methanol / 12 h / 0 - 20 °C

3: 90 percent / LiEt₃BH / tetrahydrofuran / 4 h / 60 °C

4: 60 percent / pyridine / CH₂Cl₂

5: 91 percent / tetrapropylammonium perruthenate, 4-methylmorpholine N-oxide, 4A MS / acetonitrile / 4 h

6: 90 percent / 3M aq. HCl / tetrahydrofuran / 3 h / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; tetrapropylammonium perruthennate; Cri₉₀₀ NiCl₂; lithium triethylborohydride; 4-methylmorpholine N-oxide; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

DOI:10.1016/S0040-4039(99)00366-4

Reference yield:

(R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-((2S,5S)-5-hydroxy-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-pentane-1,5-diol (226926-99-4) → C21H30O7S (226927-03-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / pyridine / CH₂Cl₂

2: 91 percent / tetrapropylammonium perruthenate, 4-methylmorpholine N-oxide, 4A MS / acetonitrile / 4 h

3: 90 percent / 3M aq. HCl / tetrahydrofuran / 3 h / 20 °C

With pyridine; hydrogenchloride; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(99)00366-4

upstream raw materials:

Acetic acid (E)-(R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-iodo-but-3-enyl ester

(R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-((2S,5S)-5-hydroxy-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-pentane-1,5-diol

Toluene-4-sulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxy-5-((2S,5S)-5-hydroxy-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-pentyl ester

Acetic acid (R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxy-5-[(2S,5S)-2,6,6-trimethyl-5-(naphthalen-1-ylcarbamoyloxy)-tetrahydro-pyran-2-yl]-pentyl ester