N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide

Base Information

Chemical Name:N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide
CAS No.:1416335-61-9
Molecular Formula:C₃₀H₂₇N₇O₄S
Molecular Weight:581.655
Hs Code.:

Synonyms:N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide

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Chemical Property of N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide

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Technology Process of N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide

There total 5 articles about N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.64%

: 1366131-01-2
4-cyano-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

: 1416336-39-4
6-bromo-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-2-amine

: 1416335-61-9
N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide

Guidance literature:: With sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 130 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1416335-61-9
N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

2: sodium dithionite / water; tetrahydrofuran / 3.42 h / 20 °C

3: acetonitrile; water; methanol / 2 h

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 130 °C / Microwave irradiation

With sodium dithionite; sodium hydrogencarbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;

Reference yield:

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 1416335-61-9
N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-4-cyanobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

2: sodium dithionite / water; tetrahydrofuran / 3.42 h / 20 °C

3: acetonitrile; water; methanol / 2 h

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 130 °C / Microwave irradiation

With sodium dithionite; sodium hydrogencarbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;