(1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1438250-47-5
Molecular Formula:C₃₃H₄₀N₂O₄
Molecular Weight:528.692
Hs Code.:

Synonyms:(1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about (1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1263209-98-8
7-(benzyloxy)-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 40141-12-6
1-(Chloromethyl)-4-(1-methylethoxy)benzene

: 1438250-47-5
(1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 7-(benzyloxy)-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline; With n-butyllithium; In tetrahydrofuran; hexane; at -80 ℃; for 0.166667h;

1-(Chloromethyl)-4-(1-methylethoxy)benzene; In tetrahydrofuran; hexane; at -98 - 0 ℃; for 2h;
DOI:10.1248/cpb.c12-00820

Reference yield:

: 1438250-47-5
(1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 1438250-54-4
(R)-7-(benzyloxy)-1-[(4-(benzyloxy)-3-[(R)-1-(4-isopropoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy]benzyl)]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid; hydrazine hydrate / ethanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol; water / 0 - 20 °C

3: palladium 10% on activated carbon; acetic acid; hydrogen / methanol / 7 h / 20 °C

4: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Reflux

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; hydrogen; caesium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In methanol; ethanol; water; 4: |Ullmann Condensation;
DOI:10.1248/cpb.c12-00820

Reference yield:

: 1438250-47-5
(1R)-7-benzyloxy-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-(4-isopropylbenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: norisoliensinine

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid; hydrazine hydrate / ethanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol; water / 0 - 20 °C

3: palladium 10% on activated carbon; acetic acid; hydrogen / methanol / 7 h / 20 °C

4: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Reflux

5: boron trichloride / dichloromethane / 1 h / -15 °C

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; hydrogen; boron trichloride; caesium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In methanol; ethanol; dichloromethane; water; 4: |Ullmann Condensation;
DOI:10.1248/cpb.c12-00820