N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide

Base Information

• Chemical Name: N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide
• CAS No.: 615562-47-5
• Molecular Formula: C₂₀H₂₇NO₂S
• Molecular Weight: 345.506
• Mol file: 615562-47-5.mol

Synonyms:N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide

Chemical Property of N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide

There total 2 articles about N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-2-pentyn-1-ol (15787-92-5) → N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide (615562-47-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: PPh₃; DIAD; Zn(N₃)2 / tetrahydrofuran / 1.5 h / 20 °C

1.2: H₂O / tetrahydrofuran / 8 h / 50 °C

1.3: HCl / tetrahydrofuran / 20 °C

2.1: 5.5 g / Et₃N / CH₂Cl₂ / 2 h / 20 °C

3.1: 84 percent / PPh₃; DIAD / tetrahydrofuran / 15 h / 20 °C

With zinc(II) azide; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.1: Mitsunobu reaction / 3.1: Mitsunobu reaction;

DOI:10.1021/ja036410f

Reference yield:

4-methylpent-2-yn-1-amine hydrochloride → N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide (615562-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.5 g / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 84 percent / PPh₃; DIAD / tetrahydrofuran / 15 h / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;

DOI:10.1021/ja036410f

Reference yield: 61.0%

N-(4,4-dimethyl-pent-2-ynyl)-4-methyl-N-(4-methyl-pent-2-ynyl)-benzenesulfonamide (615562-47-5) → 1-[4-(2,2-dimethyl-propyl)-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-propan-1-one

Guidance literature:

With cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; In water; acetone; at 20 ℃; for 40h;

DOI:10.1021/ja036410f

upstream raw materials:

4-methyl-2-pentyn-1-ol