3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol

Base Information

Chemical Name:3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol
CAS No.:911218-23-0
Molecular Formula:C₃₃H₄₂O₃Si
Molecular Weight:514.78
Hs Code.:

Synonyms:3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol

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Technology Process of 3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol

There total 1 articles about 3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 911218-22-9
2-benzyloxymethyl-3-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-hydroxycyclopentanone

: Nysted’s reagent

: 911218-23-0
3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol

Guidance literature:: Nysted’s reagent; With titanium tetrachloride; In tetrahydrofuran; at 0 ℃;

2-benzyloxymethyl-3-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-hydroxycyclopentanone; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol0615230

Reference yield: 73.0%

: 911218-23-0
3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol

: 911218-26-3
2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-3-hydroxymethyl-4-methylenecyclopentanol

Guidance literature:: With boron trichloride; In n-heptane; dichloromethane; at -40 ℃; for 0.5h;
DOI:10.1021/ol0615230

Reference yield:

: 911218-23-0
3-benzyloxymethyl-2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-4-methylenecyclopentanol

: 911218-24-1
2-[2-(tert-butyldiphenylsilanyloxy)-1-methyl-ethyl]-3-hydroxymethyl-4-methylcyclopentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / BCl₃ / CH₂Cl₂; heptane / 0.5 h / -40 °C

2: 74 percent / [Ir(cod)py(PCy₃)]PF₆; H₂ / CH₂Cl₂ / cooling

With Crabtree's catalyst; hydrogen; boron trichloride; In n-heptane; dichloromethane;
DOI:10.1021/ol0615230