(R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol

Base Information

Chemical Name:(R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol
CAS No.:1394207-40-9
Molecular Formula:C₁₅H₂₁ClN₄O₂
Molecular Weight:324.81
Hs Code.:

Synonyms:(R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol

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Chemical Property of (R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol

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Technology Process of (R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol

There total 3 articles about (R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 13482-22-9
4-hydroxycyclohexanone

: 1394070-49-5
(R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

: 1394207-40-9
(R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol

Guidance literature:: 4-hydroxycyclohexanone; (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine; With titanium tetrachloride; In dichloromethane; at 20 ℃; for 4h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 ℃; for 1h;

With ammonium chloride; In dichloromethane;

Reference yield:

: 1394070-48-4
2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine

: 1394207-40-9
(R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Chiralcel_.(R). AS-H / carbon dioxide; methanol / Resolution of racemate

2.1: titanium tetrachloride / dichloromethane / 4 h / 20 °C

2.2: 1 h / 0 °C

With titanium tetrachloride; In methanol; dichloromethane; carbon dioxide;

Reference yield:

: 1268474-50-5
2-chloro-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin -6(5H)-one

: 1394207-40-9
(R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: Chiralcel_.(R). AS-H / carbon dioxide; methanol / Resolution of racemate

3.1: titanium tetrachloride / dichloromethane / 4 h / 20 °C

3.2: 1 h / 0 °C

With lithium aluminium tetrahydride; titanium tetrachloride; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide;