2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole

Base Information

Chemical Name:2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole
CAS No.:114772-91-7
Molecular Formula:C₂₃H₂₄ClN₃O₂
Molecular Weight:409.915
Hs Code.:

Synonyms:2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole

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Chemical Property of 2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole

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Technology Process of 2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole

There total 4 articles about 2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114772-90-6
2-butyl-4-chloro-1-(4-hydroxybenzyl)-5-(hydroxymethyl)imidazole

: 22115-41-9
2-(bromomethyl)benzonitrile

: 114772-91-7
2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole

Guidance literature:: With sodium methylate; Yield given. Multistep reaction; 1.) DMF, 25 deg C, 0.25 h, 2.) 16 h;
DOI:10.1021/jm00167a008

Reference yield:

: 836-42-0
4-benzyloxybenzyl chloride

: 114772-91-7
2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 40 deg C, 4 h

2: 42 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 6 h / 760 Torr / Ambient temperature

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 16 h

With hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm00167a008

Reference yield:

: 114799-98-3
1-<4-(benzyloxy)benzyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

: 114772-91-7
2-butyl-4-chloro-1-<4-<(2-cyanobenzyl)oxy>benzyl>-5-(hydroxymethyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 6 h / 760 Torr / Ambient temperature

2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 16 h

With hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm00167a008