4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine
• CAS No.: 1313714-51-0
• Molecular Formula: C₁₅H₁₃ClN₂O
• Molecular Weight: 272.734
• Mol file: 1313714-51-0.mol

Synonyms:4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine

Chemical Property of 4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

4-Chloro-1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine

There total 2 articles about 4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

p-methoxybenzyl chloride (824-94-2) + 4-chloro-7-azaindole (55052-28-3) → 4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine (1313714-51-0)

Guidance literature:

4-chloro-7-azaindole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 0 ℃; for 19h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.04.023

Reference yield:

4-chloro-7-azaindole (55052-28-3) → 4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine (1313714-51-0)

Guidance literature:

4-chloro-7-azaindole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

p-methoxybenzyl halide; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03429

Reference yield: 90.0%

fur-2-ylboronic acid (13331-23-2) + 4-chloro-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine (1313714-51-0) → 4-(furan-2-yl)-1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (1313714-38-3)

Guidance literature:

With potassium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; for 2h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2011.04.023

upstream raw materials:

p-methoxybenzyl chloride

4-chloro-7-azaindole

Downstream raw materials:

4-(furan-2-yl)-1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine