Technology Process of Phosphoric acid dibenzyl ester (1S,4R,5R,6S)-4,5,6-tris-benzyloxy-3-methyl-cyclohex-2-enyl ester
There total 8 articles about Phosphoric acid dibenzyl ester (1S,4R,5R,6S)-4,5,6-tris-benzyloxy-3-methyl-cyclohex-2-enyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 84 percent / DMSO, acetic anhydride / Ambient temperature
2: 91 percent / tetrahydrofuran / 0.5 h / -77 °C
3: 93 percent / NaBH4 / tetrahydrofuran / Ambient temperature
4: 82 percent / DMSO, TFAA, Et3N / CH2Cl2 / 1.5 h / -77 °C
5: 94 percent / NaH / bis-(2-methoxy-ethyl) ether / 1 h / 65 °C
6: 9-BBN / tetrahydrofuran / 1) 0 deg C, 2 h, 2) room temperature, 1 h
7: 1H-tetrazole / CH2Cl2 / 2 h / Ambient temperature
8: m-CPBA / 0.75 h / -40 deg C to room temperature
With
1H-tetrazole; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; acetic anhydride; sodium hydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/jo00051a004
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 91 percent / tetrahydrofuran / 0.5 h / -77 °C
2: 93 percent / NaBH4 / tetrahydrofuran / Ambient temperature
3: 82 percent / DMSO, TFAA, Et3N / CH2Cl2 / 1.5 h / -77 °C
4: 94 percent / NaH / bis-(2-methoxy-ethyl) ether / 1 h / 65 °C
5: 9-BBN / tetrahydrofuran / 1) 0 deg C, 2 h, 2) room temperature, 1 h
6: 1H-tetrazole / CH2Cl2 / 2 h / Ambient temperature
7: m-CPBA / 0.75 h / -40 deg C to room temperature
With
1H-tetrazole; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; sodium hydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/jo00051a004
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 9-BBN / tetrahydrofuran / 1) 0 deg C, 2 h, 2) room temperature, 1 h
2: 1H-tetrazole / CH2Cl2 / 2 h / Ambient temperature
3: m-CPBA / 0.75 h / -40 deg C to room temperature
With
1H-tetrazole; 9-borabicyclo[3.3.1]nonane dimer; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00051a004
