1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate

Base Information

• Chemical Name: 1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate
• CAS No.: 1428857-06-0
• Molecular Formula: C₉H₁₁O₃S*C₁₅H₁₄ClN₂
• Molecular Weight: 456.993

Synonyms:1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate

Chemical Property of 1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate

There total 2 articles about 1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Phenyl-1-butyne (16520-62-0) → 1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate (1428857-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 20 °C

2: acetonitrile; water / 1.5 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In water; acetonitrile; 1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tetlet.2013.02.078

Reference yield:

2-Bromo-5-chloro-pyridine (40473-01-6) → 1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate (1428857-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 20 °C

2: acetonitrile; water / 1.5 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In water; acetonitrile; 1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tetlet.2013.02.078

Reference yield: 91.0%

1-amino-5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridinium 2,4,6-trimethylbenzenesulfonate (1428857-06-0) → 6-chloro-2-(2-phenylethyl)pyrazolo[1,5-a]pyridine (1428857-20-8)

Guidance literature:

With acetic acid; at 80 ℃; for 24h;

DOI:10.1016/j.tetlet.2013.02.078

upstream raw materials:

2-Bromo-5-chloro-pyridine

4-Phenyl-1-butyne

Downstream raw materials:

6-chloro-2-(2-phenylethyl)pyrazolo[1,5-a]pyridine

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