2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Base Information

Chemical Name:2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole
CAS No.:128902-26-1
Molecular Formula:C₂₄H₂₆N₂O₅S₂
Molecular Weight:486.613
Hs Code.:

Synonyms:2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

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Chemical Property of 2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

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Technology Process of 2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

There total 3 articles about 2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 128902-25-0
2-<(methylthio)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

: 101481-20-3,101481-29-2
2-<(methylsulfinyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

: 128902-26-1
2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 0 ℃; for 2h;
DOI:10.1021/jo00313a017

Reference yield:

: 99552-97-3
1,2,3,4,5,6-hexahydro-1,5-methaneoazacino<4,3-b>indole

: 128902-26-1
2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 1 N aq. NaOH / CH₂Cl₂ / 3 h / Ambient temperature

2: 91 percent / 50percent aq. NaOH / tetrabutylammonium hydrogen sulfate / benzene / 4 h / Ambient temperature

3: 22 percent / m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂; H₂O / 2 h / 0 °C

With sodium hydroxide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; benzene;
DOI:10.1021/jo00313a017

Reference yield:

: 128902-24-9
2-<(methylthio)acetyl>-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

: 128902-26-1
2-<(methylsulfonyl)acetyl>-7-tosyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / 50percent aq. NaOH / tetrabutylammonium hydrogen sulfate / benzene / 4 h / Ambient temperature

2: 22 percent / m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂; H₂O / 2 h / 0 °C

With sodium hydroxide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; benzene;
DOI:10.1021/jo00313a017