(+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Base Information

• Chemical Name: (+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid
• CAS No.: 129365-48-6
• Molecular Formula: 11C₁₈H₂₉N₂O₅P*9ClH
• Molecular Weight: 4556.69
• Mol file: 129365-48-6.mol

Synonyms:(+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Chemical Property of (+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

There total 3 articles about (+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-[3-(Diethoxy-phosphoryl)-propyl]-1-(4-phenyl-butyl)-piperazine-2-carboxylic acid methyl ester → (+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid (129365-48-6)

Guidance literature:

With hydrogenchloride; at 93 ℃; for 48h;

DOI:10.1021/jm00172a037

Reference yield:

2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate (126937-45-9) → (+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid (129365-48-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂ / 20percent Pd/C / methanol / 18 h

2: 44 percent / Na₂CO₃ / ethanol / 48 h / Heating

3: 55 percent / 6 M aq. HCl / 48 h / 93 °C

With hydrogenchloride; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00172a037

Reference yield:

methyl (+/-)-4-<3-(diethoxyphosphinyl)propyl>-2-piperazinecarboxylate (129365-29-3) → (+/-)-1-(4-phenylbutyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid (129365-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / Na₂CO₃ / ethanol / 48 h / Heating

2: 55 percent / 6 M aq. HCl / 48 h / 93 °C

With hydrogenchloride; sodium carbonate; In ethanol;

DOI:10.1021/jm00172a037

upstream raw materials:

methyl (+/-)-4-<3-(diethoxyphosphinyl)propyl>-2-piperazinecarboxylate

2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate