(R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid

Base Information

• Chemical Name: (R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid
• CAS No.: 640283-74-5
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 640283-74-5.mol

Synonyms:(R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid

Chemical Property of (R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid

There total 7 articles about (R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(((4-methoxybenzyl)oxy)methyl)acrylic acid → (R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid (640283-74-5)

Guidance literature:

With C₃₈H₄₀IrNP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); hydrogen; triethylamine; In methanol; at 45 ℃; for 0.5h; under 4560.31 Torr; enantioselective reaction; Glovebox; Autoclave;

DOI:10.1021/acs.orglett.8b01193

Reference yield: 88.0%

(2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol (160238-45-9) → (R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid (640283-74-5)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; water; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201301365

Reference yield:

O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → (R)-3-((4-methoxybenzyl)oxy)-2-methylpropanoic acid (640283-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: camphorsulfonic acid / CH₂Cl₂

2: sodium hydroxide; H₂O / methanol; tetrahydrofuran

With sodium hydroxide; camphor-10-sulfonic acid; water; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/anie.200352229

upstream raw materials:

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

O-(4-methoxybenzyl)-trichloroacetimidate

(R)-3-(4-methoxybenzyloxy)-2-methylpropyl acetate

(2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol

Downstream raw materials:

1-{[(2R,3R)-3-(methoxymethoxy)-2-methylpent-4-enyloxy]methyl}-4-methoxybenzene

methyl (R)-N-methyl-N-methoxy-3-(4-methoxybenzyloxy)-2-methylpropanoate