(2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate
CAS No.:1352212-85-1
Molecular Formula:C₂₂H₃₆N₂O₄Si
Molecular Weight:420.624
Hs Code.:

Synonyms:(2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

Suppliers and Price of (2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

There total 9 articles about (2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₃₃NO₇Si

: 62-53-3
aniline

: 1352212-85-1
(2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 20h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2011.10.010

Reference yield:

: 401564-17-8
(2S,4S)-1-(tert-butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid

: 1352212-85-1
(2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: tetrahydrofuran / 20 h / 0 °C / Inert atmosphere; Reflux

With triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.10.010

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1352212-85-1
(2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: methanol; potassium carbonate / 1 h / 20 °C / Inert atmosphere

5.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: lithium hydroxide / methanol; water / 6 h / 45 °C / Inert atmosphere

6.2: pH 3 / Inert atmosphere

7.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

8.1: tetrahydrofuran / 20 h / 0 °C / Inert atmosphere; Reflux

With 1H-imidazole; methanol; di-isopropyl azodicarboxylate; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.10.010