(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

Base Information

Chemical Name:(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid
CAS No.:136630-83-6
Molecular Formula:C₂₀H₂₉NO₅
Molecular Weight:363.454
Hs Code.:

Synonyms:(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

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Chemical Property of (4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

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Technology Process of (4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

There total 5 articles about (4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 136630-81-4
(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propionitrile

: 136630-83-6
(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

Guidance literature:: With potassium hydroxide; In methanol; for 8h; Heating;
DOI:10.1021/jm00115a016

Reference yield:

: 101669-81-2
(3R,4S)-4-<(tert-butoxycarbonyl)amino>-3-hydroxy-5-phenylpentanoic acid methyl ester

: 136630-83-6
(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / p-toluenesulfonic acid / CH₂Cl₂ / 14 h

2: Dibal / tetrahydrofuran; toluene / 1 h / 0 °C

3: triethylamine / CH₂Cl₂ / 4 h / 0 °C

4: dimethylsulfoxide / 24 h / 50 °C

5: 87 percent / 30percent aq. KOH / methanol / 8 h / Heating

With potassium hydroxide; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00115a016

Reference yield:

: 136630-94-9
(4S,5R)-4-Benzyl-5-(2-hydroxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 136630-83-6
(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / 4 h / 0 °C

2: dimethylsulfoxide / 24 h / 50 °C

3: 87 percent / 30percent aq. KOH / methanol / 8 h / Heating

With potassium hydroxide; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00115a016