3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile

Base Information

• Chemical Name: 3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile
• CAS No.: 1265231-91-1
• Molecular Formula: C₂₀H₁₇N₃O₃S
• Molecular Weight: 379.439
• Mol file: 1265231-91-1.mol

Synonyms:3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile

Chemical Property of 3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile

Chemical Property:

• Boiling Point: 660.6±65.0 °C(Predicted)
• Density: 1.25±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

3-(Dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile

There total 1 articles about 3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(1-benzenesulfonyl-1H-indol-2-yl)-3-oxo-propionitrile (1265234-00-1) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile (1265231-91-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

Reference yield: 89.0%

3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile (1265231-91-1) + 5-hydrazinyl-1H-benzo[d][1,2,3]triazole tetrachloride → 5-amino-1-(1H-benzo[d][1,2,3]triazol-5-yl)-1H-pyrazol-4-yl(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

Guidance literature:

In ethanol; for 4h; Reflux;

Reference yield: 24.0%

3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile (1265231-91-1) + methyl 5-hydrazinyl-1H-benzo[d]imidazole-2-carboxylate dihydrochloride → methyl 5-(5-amino-4-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)-1H-pyrazol-1-yl)-1H-benzo[d]imidazol-2-carboxylate

Guidance literature:

In ethanol; for 6h; Reflux;

upstream raw materials:

3-(1-benzenesulfonyl-1H-indol-2-yl)-3-oxo-propionitrile

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

[5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1-benzenesulfonyl-1H-indol-2-yl) methanone

[5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone