biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Base Information

Chemical Name:biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester
CAS No.:743460-16-4
Molecular Formula:C₃₈H₄₈N₄O₅
Molecular Weight:640.823
Hs Code.:

Synonyms:biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

There total 9 articles about biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17337-13-2
[1,1'-biphenyl]-2-yl-isocyanate

: 743460-16-4
biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 70 °C / neat (no solvent)

2: 10% palladium on activated charcoal; ammonium bicarbonate / ethanol / 40 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: sodium tris(acetoxy)borohydride / methanol; dichloromethane

6: 20 % Pd(OH)2/C; hydrogen / ethanol

7: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

8: 10% palladium on activated charcoal; hydrogen / methanol

With 10% palladium on activated charcoal; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; ammonium bicarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

: C₄₅H₅₂N₄O₅

: 743460-16-4
biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: With 10% palladium on activated charcoal; hydrogen; In methanol;
DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

: 852291-44-2
biphenyl-2-ylcarbamic acid 1-(9-hydroxynonyl)piperidin-4-yl ester

: 743460-16-4
biphenyl-2-ylcarbamic acid 1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sodium tris(acetoxy)borohydride / methanol; dichloromethane

3: 20 % Pd(OH)2/C; hydrogen / ethanol

4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

5: 10% palladium on activated charcoal; hydrogen / methanol

With 10% palladium on activated charcoal; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.01.043