(6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

Base Information

Chemical Name:(6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester
CAS No.:220643-42-5
Molecular Formula:C₃₇H₅₈N₄O₁₁Si₂
Molecular Weight:791.059
Hs Code.:

(6-{1-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

Synonyms:(6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

There total 6 articles about (6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 220643-41-4
5-(6-amino-hex-1-ynyl)-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 220643-42-5
(6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 25 ℃; for 1h;
DOI:10.1021/ja983273r

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 220643-42-5
(6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / (PhP₃)4Pd, CuI, Et₃N / dimethylformamide / 18 h / 25 °C

2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 0.33 h / 0 - 20 °C

3: 95 percent / NaN₃ / dimethylformamide / 2 h / 35 °C

4: triphenylphosphine / tetrahydrofuran / 6 h

5: 75 percent / diisopropylethylamine / tetrahydrofuran / 1 h / 25 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja983273r

Reference yield:

: 148134-86-5
2'-deoxy-3',5'-bis(O-tert-butyldimethylsilyl)-5-iodouridine

: 220643-42-5
(6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl)-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / (PhP₃)4Pd, CuI, Et₃N / dimethylformamide / 18 h / 25 °C

2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 0.33 h / 0 - 20 °C

3: 95 percent / NaN₃ / dimethylformamide / 2 h / 35 °C

4: triphenylphosphine / tetrahydrofuran / 6 h

5: 75 percent / diisopropylethylamine / tetrahydrofuran / 1 h / 25 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja983273r