7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

Base Information

Chemical Name:7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one
CAS No.:1303510-19-1
Molecular Formula:C₁₄H₁₂FIN₄O₃
Molecular Weight:430.177
Hs Code.:

Synonyms:7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

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Chemical Property of 7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

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Technology Process of 7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

There total 4 articles about 7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1303510-09-9
1-benzyl-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

: 1303510-19-1
7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

Guidance literature:: 1-benzyl-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one; With hydrogen bromide; acetic acid; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; ethyl acetate; Cooling with ice-water;

Reference yield:

: 1303510-05-5
trifluoro-methanesulfonic acid 1-benzyl-6-methyl-8-nitro-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-7-yl ester

: 1303510-19-1
7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1 h / Reflux

2.1: silver tetrafluoroborate / dichloromethane / 0.5 h / -50 °C / Inert atmosphere

2.2: 1 h / -50 °C / Inert atmosphere

3.1: hydrogen bromide; acetic acid / 2 h / 20 °C

3.2: Cooling with ice-water

With potassium phosphate; silver tetrafluoroborate; hydrogen bromide; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene;

Reference yield:

: 1303510-04-4
1-benzyl-7-hydroxy-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

: 1303510-19-1
7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 4 h / -78 - 20 °C

2.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1 h / Reflux

3.1: silver tetrafluoroborate / dichloromethane / 0.5 h / -50 °C / Inert atmosphere

3.2: 1 h / -50 °C / Inert atmosphere

4.1: hydrogen bromide; acetic acid / 2 h / 20 °C

4.2: Cooling with ice-water

With potassium phosphate; silver tetrafluoroborate; hydrogen bromide; acetic acid; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene;