malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

Base Information

Chemical Name:malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester
CAS No.:910127-01-4
Molecular Formula:C₃₆H₆₂N₄O₁₄S₂
Molecular Weight:839.039
Hs Code.:

malonic acid 3-[2-(2-{2-[3-(4-<i>tert</i>-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester <i>tert</i>-butyl ester

Synonyms:malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

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Chemical Property of malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

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Technology Process of malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

There total 1 articles about malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 138148-35-3,141630-68-4,16816-67-4,303-05-9
D-pantethine

: 40052-13-9
mono-tert-butyl malonate

: 910127-01-4
malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 60 ℃; for 36h;
DOI:10.1021/jm060732n

Reference yield:

: 910127-01-4
malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

: malonic acid mono-(3-{2-[2-({[5-amino-6-(4,6-diamino-2,3-dihydroxy-cyclohexyloxy)-3,4-dihydroxy-tetrahydro-pyran-2-ylmethyl]-carbamoyl}-methylsulfanyl)-ethylcarbamoyl]-ethylcarbamoyl}-3-hydroxy-2,2-dimethyl-propyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: DTT; DIPEA / acetone / Sonication

2: acetone / 1 h

3: TFA; anisole / CH₂Cl₂ / 16 h / 20 °C

With DL-dithiothreitol; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetone;
DOI:10.1021/jm060732n

Reference yield:

: 910127-01-4
malonic acid 3-[2-(2-{2-[3-(4-tert-butoxycarbonylacetoxy-2-hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

: 910865-99-5
malonic acid 3-{2-[2-({[5-amino-6-(4,6-diamino-2,3-dihydroxy-cyclohexyloxy)-3,4-dihydroxy-tetrahydro-pyran-2-ylmethyl]-carbamoyl}-methylsulfanyl)-ethylcarbamoyl]-ethylcarbamoyl}-3-hydroxy-2,2-dimethyl-propyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DTT; DIPEA / acetone / Sonication

2: acetone / 1 h

With DL-dithiothreitol; N-ethyl-N,N-diisopropylamine; In acetone;
DOI:10.1021/jm060732n