<<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid

Base Information

Chemical Name:<<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid
CAS No.:156078-98-7
Molecular Formula:C₁₇H₂₃ClN₂O₉S
Molecular Weight:466.897
Hs Code.:

Synonyms:<<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid

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Chemical Property of <<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid

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Technology Process of <<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid

There total 5 articles about <<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 156078-99-8
di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

: 156078-98-7
<<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid

Guidance literature:: With trifluoroacetic acid; for 0.5h; Ambient temperature;
DOI:10.1021/jm00026a013

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 156078-98-7
<<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / Et₃N / CHCl₃ / 5 h / Ambient temperature

2: 83 percent / ammonium formate / 10percent Pd/C / ethanol / 0.33 h / Ambient temperature

3: AcOH / 22 h / Ambient temperature

4: 43 percent / pyridine / a) 2 deg C, 20 min, b) 50 deg C, 10 min

5: 95 percent / TFA / 0.5 h / Ambient temperature

With pyridine; ammonium formate; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; chloroform;
DOI:10.1021/jm00026a013

Reference yield:

: 156079-00-4
di-tert-butyl <<(4-nitrophenyl)oxy>carbonyl>-L-glutamate

: 156078-98-7
<<<4-<2-<(mesyloxy)ethyl>(2-chloroethyl)amino>phenyl>oxy>carbonyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / ammonium formate / 10percent Pd/C / ethanol / 0.33 h / Ambient temperature

2: AcOH / 22 h / Ambient temperature

3: 43 percent / pyridine / a) 2 deg C, 20 min, b) 50 deg C, 10 min

4: 95 percent / TFA / 0.5 h / Ambient temperature

With pyridine; ammonium formate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00026a013