5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide

Base Information

Chemical Name:5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide
CAS No.:1026710-89-3
Molecular Formula:C₃₃H₃₂N₂O₃
Molecular Weight:504.629
Hs Code.:

Synonyms:5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide

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Chemical Property of 5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide

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Technology Process of 5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide

There total 4 articles about 5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6672-66-8
5,7-dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid diethyl ester

: 1026710-89-3
5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / ethanol; H₂O / 48 h / Ambient temperature

2: N-methylmorpholine, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / Ambient temperature

3: KOH / tetrahydrofuran; H₂O / 2 h / 80 °C

4: 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / 12 h

With 4-methyl-morpholine; potassium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm980112p

Reference yield:

: 5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid ethyl ester

: 1026710-89-3
5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / Ambient temperature

2: KOH / tetrahydrofuran; H₂O / 2 h / 80 °C

3: 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / 12 h

With 4-methyl-morpholine; potassium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water;
DOI:10.1021/jm980112p

Reference yield:

: 211301-26-7
6-Benzyloxycarbamoyl-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-6-carboxylic acid ethyl ester

: 1026710-89-3
5,7-Dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid benzyloxy-amide (3-phenyl-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / tetrahydrofuran; H₂O / 2 h / 80 °C

2: 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / 12 h

With potassium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water;
DOI:10.1021/jm980112p