2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide

Base Information

Chemical Name:2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide
CAS No.:1421921-72-3
Molecular Formula:C₂₃H₂₈N₆OS
Molecular Weight:436.581
Hs Code.:

Synonyms:2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide

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Chemical Property of 2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide

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Technology Process of 2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide

There total 6 articles about 2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421922-88-4
2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-1,3-thiazole-4-carboxylic acid hydrobromide

: 132664-85-8
(5-methylpyrazine-2-yl)methylamine

: 1421921-72-3
2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1421922-04-4
2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide

: 1421921-72-3
2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; iron; water / ethanol / 2 h / Reflux

2.1: oxalyl dichloride / chloroform / 0.17 h / 20 °C

2.2: 24 h / 20 °C

3.1: isopropyl alcohol / 0.5 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With oxalyl dichloride; water; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1421922-05-5
2-(4-amino-2,5-dimethylphenyl)ethanethioamide

: 1421921-72-3
2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / chloroform / 0.17 h / 20 °C

1.2: 24 h / 20 °C

2.1: isopropyl alcohol / 0.5 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In chloroform; N,N-dimethyl-formamide; isopropyl alcohol;