(2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

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Chemical Name:(2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide
CAS No.:1569085-47-7
Molecular Formula:C₂₇H₂₄Cl₂F₄N₄O₅S
Molecular Weight:663.477
Hs Code.:

(2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

Synonyms:(2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

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Chemical Property of (2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

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Technology Process of (2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

There total 2 articles about (2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 374-01-6,17556-48-8,17628-73-8,3539-97-7
(S)-1,1,1-trifluoro-2-propanol

: 1569085-15-9
(2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-fluorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

: 1569085-47-7
(2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

Reference yield:

: 1438430-34-2
1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarboxylic acid

: C₁₅H₁₅ClFN₃O₃S

: 1569085-47-7
(2S,4R)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chloro-4-((S)-1,1,1-trifluoropropan-2-yloxy)phenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 22 °C

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;