erythro-3-Fluorophenylaniline isopropyl ester

Base Information

• Chemical Name: erythro-3-Fluorophenylaniline isopropyl ester
• CAS No.: 75198-00-4
• Molecular Formula: C₁₂H₁₆FNO₂
• Molecular Weight: 225.263
• Mol file: 75198-00-4.mol

Synonyms:erythro-3-Fluorophenylaniline isopropyl ester

Chemical Property of erythro-3-Fluorophenylaniline isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-3-Fluorophenylaniline isopropyl ester

There total 15 articles about erythro-3-Fluorophenylaniline isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

threo-2-amino-3-hydroxy-3-phenylpropanoic acid (69-96-5,1078-17-7,2584-74-9,2584-75-0,6254-48-4,7352-06-9,7687-36-7,7695-56-9,32946-42-2,50897-27-3,68296-26-4,109120-55-0) → erythro-3-Fluorophenylaniline isopropyl ester (75198-00-4) + threo-3-Fluorophenylaniline isopropyl ester (75197-99-8,73475-93-1,75198-00-4,79617-86-0,79617-88-2)

Guidance literature:

With diethylamino-sulfur trifluoride; Multistep reaction. Title compound not separated from byproducts; 1.) HF, -40 deg C, 2 h;

DOI:10.1016/0040-4039(80)80243-7

Reference yield:

threo-2-amino-3-hydroxy-3-phenylpropanoic acid (69-96-5,1078-17-7,2584-74-9,2584-75-0,6254-48-4,7352-06-9,7687-36-7,7695-56-9,32946-42-2,50897-27-3,68296-26-4,109120-55-0) → erythro-3-Fluorophenylaniline isopropyl ester (75198-00-4) + threo-3-Fluorophenylaniline isopropyl ester (75197-99-8,73475-93-1,75198-00-4,79617-86-0,79617-88-2)

Guidance literature:

With diethylamino-sulfur trifluoride; Multistep reaction. Title compound not separated from byproducts; 1.) HF, -40 deg C, 2 h;

DOI:10.1016/0040-4039(80)80243-7

Reference yield:

cinnamamide (621-79-4,22031-64-7) → threo-3-Fluorophenylaniline isopropyl ester (75197-99-8,73475-93-1,75198-00-4,79617-86-0,79617-88-2)

Guidance literature:

Multi-step reaction with 4 steps

1: Br₂ / CCl₄

2: NH₃ / dimethylsulfoxide

3: pyridinium poly(hydrogen fluoride) / CH₂Cl₂ / Ambient temperature

4: H⁽¹⁺⁾ / Heating

With ammonia; bromine; hydrogen cation; pyridine hydrogenfluoride; In tetrachloromethane; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/S0022-1139(00)85554-2

upstream raw materials:

threo-2-amino-3-hydroxy-3-phenylpropanoic acid

cis-(+/-)-3-phenylaziridine-2-carbonitrile

isopropyl alcohol

α,β-dibromocinnamonitrile

Downstream raw materials:

2-Acetylamino-3-fluoro-3-phenyl-propionic acid isopropyl ester

N-[1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-fluoro-2-(3-nitro-phenyl)-ethyl]-2,2-dichloro-acetamide

N-[1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-fluoro-2-(4-nitro-phenyl)-ethyl]-2,2-dichloro-acetamide

threo-2-(dichloroacetamido)-3-fluoro-3-(m-nitrophenyl)-1-propanol