3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Base Information

Chemical Name:3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CAS No.:941688-05-7
Molecular Formula:C₁₇H₁₈N₆
Molecular Weight:306.37
Hs Code.:
Mol file:941688-05-7.mol

Synonyms:3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

Suppliers and Price of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-Ruxolitinib
25mg
$ 2130.00

Medical Isotopes, Inc.
rac-Ruxolitinib
1 mg
$ 410.00

Chemenu
3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile 95%+
10mg
$ 980.00

Total 9 raw suppliers

Chemical Property of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Chemical Property:

PKA:11.63±0.50(Predicted)
Density:1.40±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

rac-Ruxolitinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses rac-Ruxolitinib is the racemic analogue of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.

Technology Process of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

There total 1 articles about 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1153949-38-2
racemic-3-cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile

: 4-bromo-7H-pyrrolo[2,3-d]pyrimidine

: 941688-05-7,941685-37-6
3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 120 ℃; for 12h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.jmedchem.0c01952

Reference yield:

: 941688-05-7,941685-37-6
3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

: 941678-49-5,941685-37-6
ruxolitinib

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 20 - 70 °C

2: sodium hydroxide / water; ethyl acetate / 20 - 25 °C / pH 9.5 - 10

With sodium hydroxide; In water; ethyl acetate; acetonitrile;