4-(2-Aminopropyl)phenol

Base Information

• Chemical Name: 4-(2-Aminopropyl)phenol
• CAS No.: 103-86-6
• Deprecated CAS: 1518-86-1
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2922299090
• European Community (EC) Number: 203-152-8
• NSC Number: 170995
• UNII: FQR280JW2N
• DSSTox Substance ID: DTXSID3023134
• Nikkaji Number: J182.169E
• Wikipedia: 4-Hydroxyamphetamine
• Wikidata: Q5955531
• NCI Thesaurus Code: C61787
• RXCUI: 7839
• Pharos Ligand ID: WFXYHQVQ9R3W
• Metabolomics Workbench ID: 143601
• ChEMBL ID: CHEMBL1546
• Mol file: 103-86-6.mol

Synonyms:Hydrobromide, Hydroxyamphetamine;Hydroxyamfetamine;Hydroxyamphetamin;Hydroxyamphetamine;Hydroxyamphetamine Hydrobromide;Hydroxyphenylisopropylamine;Methyltyramine;Norpholedrin;Oxyamphetamine;p Hydroxyamphetamine;p-Hydroxyamphetamine;para Hydroxyamphetamine;para-Hydroxyamphetamine;Paredrine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 4-(2-Aminopropyl)phenol

Chemical Property:

• Appearance/Colour: white like or light brown crystalline powder
• Melting Point: 125-126 °C
• Boiling Point: 279.2 °C at 760 mmHg
• PKA: 9.83±0.15(Predicted)
• Flash Point: 122.7 °C
• PSA: 46.25000
• Density: 1.07 g/cm³
• LogP: 1.98220
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)O)N

Technology Process of 4-(2-Aminopropyl)phenol

There total 17 articles about 4-(2-Aminopropyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(4-benzyloxy-phenyl)-1-methyl-ethylamine (7176-39-8,71488-45-4) → p-hydroxyamphetamine (103-86-6,1518-86-1)

Guidance literature:

With palladium on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; Sealed tube;

DOI:10.1002/anie.201806490

Reference yield: 94.0%

1-(4-hydroxyphenyl)propan-2-one oxime → p-hydroxyamphetamine (103-86-6,1518-86-1)

Guidance literature:

With ammonium formate; zinc; In methanol; for 0.05h; Heating;

Reference yield: 88.0%

4-methoxyphenylacetone (770-39-8) → p-hydroxyamphetamine (103-86-6,1518-86-1)

Guidance literature:

With ammonia; hydrogen; In tetrahydrofuran; at 120 ℃; for 15h;

DOI:10.1126/science.aan6245

upstream raw materials:

2-amino-1-(4-methyoxyphenyl)propane

(+/-)-4-(2-amino-propyl)-aniline

2-amino-3-(4-hydroxy-phenyl)-2-methyl-propionic acid

2-amino-1-phenylpropane

Downstream raw materials:

4-[2-(1-methyl-2-phenyl-ethylamino)-propyl]-phenol

[2-(4-Hydroxy-phenyl)-1-methyl-ethyl]-carbamic acid 2-formyl-phenyl ester

4-[2-(2-Hydroxy-2-naphthalen-2-yl-ethylamino)-propyl]-phenol

(2,6-Dichloro-4-{1-hydroxy-2-[2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-carbamic acid ethyl ester

Refernces

• 1、 Alles. "-". . p. 271,273. Retrieved 1932.
• 2、 Huang, Zheng,Kwon, Ohhyeon,Huang, Haiyan,Fadli, Aziz,Marat, Xavier,Moreau, Magali,Lumb, Jean-Philip. "A Bioinspired Synthesis of Polyfunctional Indoles". . p. 11963 - 11967. Retrieved 2018/09/11.
• 3、 -. "NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS". Page/Page column 71. . Retrieved 2013/07/05.