4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate

Base Information

Chemical Name:4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate
CAS No.:1343496-00-3
Molecular Formula:C₃₅H₄₆N₄O₄
Molecular Weight:586.775
Hs Code.:

Synonyms:4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate

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Chemical Property of 4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate

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Technology Process of 4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate

There total 5 articles about 4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: decanedioic acid mono-(4-vinyl-benzyl) ester

: 1234564-83-0
N-(7-amino-1,8-naphthyridin-2-yl)-2-ethylhexanamide

: 1343496-00-3
4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate

Guidance literature:: decanedioic acid mono-(4-vinyl-benzyl) ester; N-(7-amino-1,8-naphthyridin-2-yl)-2-ethylhexanamide; With dmap; In dichloromethane; at 20 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja2069278

Reference yield:

: 1931-44-8
2-amino-8H-7-oxo-[1,8]-naphthyridine

: 1343496-00-3
4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / pyridine / 100 °C / Inert atmosphere

2.1: phosphorus tribromide / 110 °C / Inert atmosphere

3.1: copper(I) oxide; ammonium hydroxide / 1,2-dimethoxyethane; diethylene glycol dimethyl ether; water / 20 °C / Inert atmosphere

4.1: dmap / dichloromethane / 0.17 h / 20 °C

4.2: 20 °C / Inert atmosphere

With copper(I) oxide; dmap; phosphorus tribromide; ammonium hydroxide; triethylamine; In pyridine; 1,2-dimethoxyethane; dichloromethane; diethylene glycol dimethyl ether; water;
DOI:10.1021/ja2069278

Reference yield:

: 845548-22-3
2-ethyl-N-(7-oxo-7,8-dihydro-1,8-naphthyridin-2-yl)hexanamide

: 1343496-00-3
4-vinylbenzyl 10-((7-(2-ethylhexanamido)-1,8-naphthyridin-2-yl)amino)-10-oxodecanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide / 110 °C / Inert atmosphere

2.1: copper(I) oxide; ammonium hydroxide / 1,2-dimethoxyethane; diethylene glycol dimethyl ether; water / 20 °C / Inert atmosphere

3.1: dmap / dichloromethane / 0.17 h / 20 °C

3.2: 20 °C / Inert atmosphere

With copper(I) oxide; dmap; phosphorus tribromide; ammonium hydroxide; In 1,2-dimethoxyethane; dichloromethane; diethylene glycol dimethyl ether; water;
DOI:10.1021/ja2069278