(S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane

Base Information

• Chemical Name: (S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane
• CAS No.: 149035-19-8
• Molecular Formula: C₂₉H₅₂O₃
• Molecular Weight: 448.73
• Mol file: 149035-19-8.mol

Synonyms:(S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane

Chemical Property of (S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane

There total 3 articles about (S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-octadecanol (112-92-5) + (S)-(2-phenylmethoxyethyl)oxirane (85960-55-0) → (S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane (149035-19-8)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1139/v93-030

Reference yield:

(S)-4-benzyloxy-1,2-butanediol (71998-69-1,86990-91-2,104973-80-0,69985-32-6) → (S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane (149035-19-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / pyridine / CHCl₃ / a) 0 deg C, 2.5 h, b) r.t., 2 h

2: 98 percent / K₂CO₃ / methanol / a) -10 deg C, 3 h, b) r.t., 2 h

3: 97 percent / BF₃*Et₂O / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; boron trifluoride diethyl etherate; potassium carbonate; In methanol; dichloromethane; chloroform;

DOI:10.1139/v93-030

Reference yield:

(S)-toluene-4-sulfonic acid 3-benzyloxy-2-hydroxy-propyl ester (85960-54-9) → (S)-4-Benzyloxy-2-hydroxy-1-octadecyloxybutane (149035-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / K₂CO₃ / methanol / a) -10 deg C, 3 h, b) r.t., 2 h

2: 97 percent / BF₃*Et₂O / CH₂Cl₂ / 24 h / Ambient temperature

With boron trifluoride diethyl etherate; potassium carbonate; In methanol; dichloromethane;

DOI:10.1139/v93-030

upstream raw materials:

1-octadecanol

(S)-(2-phenylmethoxyethyl)oxirane

(S)-4-benzyloxy-1,2-butanediol

(S)-toluene-4-sulfonic acid 3-benzyloxy-2-hydroxy-propyl ester

Downstream raw materials:

(S)-2-Acetyloxy-4-benzyloxy-1-octadecyloxybutane