2,7-Dimethoxy-1-naphthaldehyde

Base Information

• Chemical Name: 2,7-Dimethoxy-1-naphthaldehyde
• CAS No.: 51385-93-4
• Molecular Formula: C13H12O3
• Molecular Weight: 216.235
• Hs Code.: 2912499000
• NSC Number: 159554
• DSSTox Substance ID: DTXSID10303650
• Wikidata: Q82049035
• Mol file: 51385-93-4.mol

Synonyms:2,7-dimethoxy-1-naphthaldehyde;51385-93-4;2,7-dimethoxynaphthalene-1-carbaldehyde;ASISCHEM R28379;NSC159554;2,7-Dimethoxynaphthaldehyde;SCHEMBL5227187;DTXSID10303650;PTTJQHKRNJYUGV-UHFFFAOYSA-N;BCA38593;BBL023451;MFCD00453091;STK387643;AKOS000113261;NSC-159554;2,7-dimethoxy-naphthalene-1-carbaldehyde;VS-07433;AM20040600;CS-0117179;SR-01000234716;SR-01000234716-1

Chemical Property of 2,7-Dimethoxy-1-naphthaldehyde

Chemical Property:

• Vapor Pressure: 4.04E-06mmHg at 25°C
• Boiling Point: 384.6°C at 760 mmHg
• Flash Point: 177.9°C
• PSA: 35.53000
• Density: 1.18g/cm³
• LogP: 2.66950
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 216.078644241
• Heavy Atom Count: 16
• Complexity: 241

Purity/Quality:

2,7-dimethoxynaphthalene-1-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=CC(=C2C=O)OC

Technology Process of 2,7-Dimethoxy-1-naphthaldehyde

There total 12 articles about 2,7-Dimethoxy-1-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

difluoromethyl phenyl sulfide (1535-67-7) + 2,7-Dimethoxynaphthalene (3469-26-9) → 2,7-dimethoxy-1-naphthalenecarbaldehyde (51385-93-4)

Guidance literature:

difluoromethyl phenyl sulfide; 2,7-Dimethoxynaphthalene; With tin(IV) chloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1055/s-0036-1591545

Reference yield: 95.3%

2,7-Dimethoxynaphthalene (3469-26-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,7-dimethoxy-1-naphthalenecarbaldehyde (51385-93-4)

Guidance literature:

With trichlorophosphate; for 0.05h; Microwave irradiation;

Reference yield: 95.3%

2,7-Dimethoxynaphthalene (3469-26-9) → 2,7-dimethoxy-1-naphthalenecarbaldehyde (51385-93-4)

Guidance literature:

With dichloromethyl ether; titanium tetrachloride; In dichloromethane; at 0 ℃;

DOI:10.1002/cjoc.202000342

upstream raw materials:

2,7-Dimethoxynaphthalene

N,N-dimethyl-formamide

malonic acid

tetradeuterio-malonic acid

Downstream raw materials:

3-(2,7-dimethoxynaphthalen-1-yl)-1-(2-methoxyphenyl)propen-1-one

3-(2,7-dimethoxynaphthalen-1-yl)-1-(3,4-dimethoxyphenyl)propen-1-one