1-[N²-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

Base Information

• Chemical Name: 1-[N²-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine
• CAS No.: 204693-24-3
• Molecular Formula: C₄₄H₅₀Br₂N₆O₇
• Molecular Weight: 934.725

Synonyms:1-[N²-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

Chemical Property of 1-[N²-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(9H-fluoren-9-yl)methyl((R)-1-(((S)-6-((tert-butoxycarbonyl)amino)-1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)hexan-2-yl)amino)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-[N²-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

There total 4 articles about 1-[N²-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[N2-(phenylmethoxycarbonyl)-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine (204692-51-3) → 1-[N2-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine (204693-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / H₂; aq. potassium hydrogenesulfate / Pd/C / methanol / 20 °C / 2250.18 Torr

2: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

With potassium hydrogensulfate; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0490641

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → 1-[N2-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine (204693-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

2: 97 percent / H₂; aq. potassium hydrogenesulfate / Pd/C / methanol / 20 °C / 2250.18 Torr

3: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

With potassium hydrogensulfate; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0490641

Reference yield:

4-(piperazin-1-yl)pyridine (1008-91-9) → 1-[N2-[3,5-dibromo-N-(9-fluorenylmethoxycarbonyl)-D-tyrosyl]-N6-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine (204693-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

2: 97 percent / H₂; aq. potassium hydrogenesulfate / Pd/C / methanol / 20 °C / 2250.18 Torr

3: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

With potassium hydrogensulfate; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0490641

upstream raw materials:

1-[N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

N-(9-fluorenylmethoxycarbonyl)-3,5-dibromo-D-tyrosine

1-[N²-(phenylmethoxycarbonyl)-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

Z-Lys(Boc)-OH

Downstream raw materials:

1-[N²-[N-[[4-(1,3-dihydro-2(2H)-oxobenzimidazol-1-yl)-1-piperidinyl]carbonyl]-3,5-dibromo-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine

1-[N²-[N-[[4-[2(3H)-oxobenzoxazol-3-yl]-1-piperidinyl]carbonyl]-3,5-dibromo-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine

1-[N²-[3,5-dibromo-N-[[4-[N-(aminocarbonyl)phenylamino]-1-piperidinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)-piperazine

1-[N²-[3,5-dibromo-N-[[4-(2-methoxyphenyl)-1-piperazinyl]carbonyl]-D-tyrosyl]-N⁶-(1,1-dimethylethoxycarbonyl)-L-lysyl]-4-(4-pyridinyl)piperazine

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